Publikationen der Arbeitsgruppe "Molekulargenetik oraler Entzündungskrankheiten"

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  • Munz M, Willenborg C, Richter GM, Jockel-Schneider Y, Graetz C, Staufenbiel I, Wellmann J, Berger K, Krone B, Hoffmann P, Velde NV, Uitterlinden AG, Groot LCPGM, Sawalha A, Direskeneli H, Saruhan-Direskeneli G, Guzeldemir-Akcakanat E, Keceli G, Laudes M, Noack B, Teumer A, Holtfreter B, Kocher T, Eickholz P, Meyle J, Doerfer C, Bruckmann C, Lieb W, Franke A, Schreiber S, Nohutcu RM, Erdmann J, Loos BG, Jepsen S, Dommisch H, Schaefer AS


    A genome-wide association study identifies nucleotide variants at SIGLEC5 and DEFA1A3 as risk loci for periodontitis.

    Hum Mol Genet. 2017; 26(13):2577-2588.
  • Munz M, Chen H, Jockel-Schneider Y, Adam K, Hoffman P, Berger K, Kocher T, Meyle J, Eickholz P, Doerfer C, Laudes M, Uitterlinden A, Lieb W, Franke A, Schreiber S, Offenbacher S, Divaris K, Bruckmann C, Loos BG, Jepsen S, Dommisch H, Schaefer AS.


    A haplotype block downstream of plasminogen is associated with chronic and aggressive periodontitis.

    J Clin Periodontol. 2017; 44(10):962-970.
  • Shusterman A, Munz M, Richter G, Jepsen S, Lieb W, Krone B, Hoffman P, Laudes M, Wellmann J, Berger K, Kocher T, Offenbacher S, Divaris K, Franke A, Schreiber S, Dommisch H, Weiss E, Schaefer AS*, Houri-Haddad Y*, Iraqi FA*.


    The PF4/PPBP/CXCL5 Gene Cluster Is Associated with Periodontitis.

    J Dent Res 2017 Jul; 96(8):945-952.
  • Offenbacher S, Divaris K, Barros SP, Moss KL, Marchesan JT, Morelli T, Zhang S,im S, Sun L, Beck JD, Laudes M, Munz M, Schaefer AS, North KE.


    Genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease.

    Hum Mol Genet 2016; 25(10):2113-2129.
  • Schaefer A.S., Bochenek, G. Jochens, A., Dommisch, H., Graetz C, Thien A, Jockel-Schneider Y, Harks I, Staufenbiel I ,Wijmenga C, Linden G, J, Guzeldemir E, Cine N, Folwaczny M, Noack B, Gieger C, Waldenberger M, Lieb W, Erdmann J, König I, Meyle J, Eickholz P, Bruckmann C, Doerfer C, Jepsen S, Loos BG, Schreiber S.


    Genetic evidence for PLASMINOGEN as a shared genetic risk factor of Coronary Artery Disease and Periodontitis.

    Circ Cardiovasc Genet 2014; doi:10.1161/CIRCGENETICS.114. 000554
  • Freitag-Wolf, S., Dommisch, H., Graetz, C., Jockel-Schneider, Y., Harks, I., Staufenbiel, I., Meyle, J., Eickholz, P., Noack, B., Bruckmann, C., Gieger, C., Jepsen, S., Lieb, W., Schreiber, S., Konig, I. R. & Schaefer, A. S.


    Genome-wide exploration identifies sex-specific genetic effects of alleles upstream NPY to increase the risk of severe periodontitis in men.

    J Clin Periodontol. 2014; doi:10.1111(jcpe.12317)
  • Bochenek, G., Hasler, R., El Mokhtari, N. E., Konig, I. R., Loos, B. G., Jepsen, S., Rosenstiel, P., Schreiber, S. & Schaefer, A. S.


    The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10.

    Hum Mol Genet. 2013; doi:ddt299 [pii] 10.1093(hmg):ddt299.
  • Schaefer, A. S., Richter, G. M., Dommisch, H., Reinartz, M., Nothnagel, M., Noack, B., Laine, M. L., Folwaczny, M., Groessner-Schreiber, B., Loos, B. G., Jepsen, S. & Schreiber, S.


    CDKN2BAS is associated with periodontitis in different European populations and is activated by bacterial infection.

    J Med Genet 2013; 48:38-47.
  • Keller, A., Leidinger, P., Bauer, A., Elsharawy, A., Haas, J., Backes, C., Wendschlag, A., Giese, N., Tjaden, C., Ott, K., Werner, J., Hackert, T., Ruprecht, K., Huwer, H., Huebers, J., Jacobs, G., Rosenstiel, P., Dommisch, H., Schaefer, A.S., Muller-Quernheim, J., Wullich, B., Keck, B., Graf, N., Reichrath, J., Vogel, B., Nebel, A., Jager, S. U., Staehler, P., Amarantos, I., Boisguerin, V., Staehler, C., Beier, M., Scheffler, M., Buchler, M. W., Wischhusen, J., Haeusler, S. F., Dietl, J., Hofmann, S., Lenhof, H. P., Schreiber, S., Katus, H. A., Rottbauer, W., Meder, B., Hoheisel, J. D., Franke, A. & Meese, E.


    Toward the blood-borne miRNome of human diseases

    Nat Methods 2011; 8:841-843.
  • Schaefer, A. S., Richter, G. M., Nothnagel, M., Manke, T., Dommisch, H., Jacobs, G., Arlt, A., Rosenstiel, P., Noack, B., Groessner-Schreiber, B., Jepsen, S., Loos, B. G. & Schreiber, S.


    A genome-wide association study identifies GLT6D1 as a susceptibility locus for periodontitis.

    Hum Mol Genet 2010; 19:553-562.
  • Schaefer, A. S., Richter, G. M., Groessner-Schreiber, B., Noack, B., Nothnagel, M., El Mokhtari, N. E., Loos, B. G., Jepsen, S. & Schreiber, S.


    Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis.

    PLoS Genet 2009; 5:e1000378.

Publikation innerhalb wissenschaftlicher Konsortien

  • IBC-50K-CAD-Consortium


    Large-scale gene-centric analysis identifies novel variants for coronary artery disease.

    PLoS Genet 2011; 7
  • 6. Schunkert, H., Konig, I. R., Kathiresan, S., Reilly, M. P., Assimes, T. L., Holm, H., Preuss, M., Stewart, A. F., Barbalic, M., Gieger, C., Absher, D., Aherrahrou, Z., Allayee, H., Altshuler, D., Anand, S. S., Andersen, K., Anderson, J. L., Ardissino, D., Ball, S. G., Balmforth, A. J., Barnes, T. A., Becker, D. M., Becker, L. C., Berger, K., Bis, J. C., Boekholdt, S. M., Boerwinkle, E., Braund, P. S., Brown, M. J., Burnett, M. S., Buysschaert, I., Carlquist, J. F., Chen, L., Cichon, S., Codd, V., Davies, R. W., Dedoussis, G., Dehghan, A., Demissie, S., Devaney, J. M., Diemert, P., Do, R., Doering, A., Eifert, S., Mokhtari, N. E., Ellis, S. G., Elosua, R., Engert, J. C., Epstein, S. E., de Faire, U., Fischer, M., Folsom, A. R., Freyer, J., Gigante, B., Girelli, D., Gretarsdottir, S., Gudnason, V., Gulcher, J. R., Halperin, E., Hammond, N., Hazen, S. L., Hofman, A., Horne, B. D., Illig, T., Iribarren, C., Jones, G. T., Jukema, J. W., Kaiser, M. A., Kaplan, L. M., Kastelein, J. J., Khaw, K. T., Knowles, J. W., Kolovou, G., Kong, A., Laaksonen, R., Lambrechts, D., Leander, K., Lettre, G., Li, M., Lieb, W., Loley, C., Lotery, A. J., Mannucci, P. M., Maouche, S., Martinelli, N., McKeown, P. P., Meisinger, C., Meitinger, T., Melander, O., Merlini, P. A., Mooser, V., Morgan, T., Muhleisen, T. W., Muhlestein, J. B., Munzel, T., Musunuru, K., Nahrstaedt, J., Nelson, C. P., Nothen, M. M., Olivieri, O., Patel, R. S., Patterson, C. C., Peters, A., Peyvandi, F., Qu, L., Quyyumi, A. A., Rader, D. J., Rallidis, L. S., Rice, C., Rosendaal, F. R., Rubin, D., Salomaa, V., Sampietro, M. L., Sandhu, M. S., Schadt, E., Schafer, A.S. et al.


    Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.

    Nat Genet 2011; 43:333-338.
  • 5. Voight, B. F., Peloso, G. M., Orho-Melander, M., Frikke-Schmidt, R., Barbalic, M., Jensen, M. K., Hindy, G., Holm, H., Ding, E. L., Johnson, T., Schunkert, H., Samani, N. J., Clarke, R., Hopewell, J. C., Thompson, J. F., Li, M., Thorleifsson, G., Newton-Cheh et al.


    Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study.

    Lancet 2012; 380:572-580.
  • 4. Chan, K., Patel, R. S., Newcombe, P., Nelson, C. P., Qasim, A., Epstein, S. E., Burnett, S., Vaccarino, V. L., Zafari, A. M., Shah, S. H., Anderson, J. L., Carlquist, J. F., Hartiala, J., Allayee, H., Hinohara, K., Lee, B. S., Erl, A., Ellis, K. L., Goel, A., Schaefer, A. S.et al


    Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis.

    J Am Coll Cardiol 2013; 61:957-970.
  • 3. Deloukas, P., Kanoni, S., Willenborg, C., Farrall, M., Assimes, T. L., Thompson, J. R., Ingelsson, E., Saleheen, D., Erdmann, J., Goldstein, B. A., Stirrups, K., Konig et al.


    Large-scale association analysis identifies new risk loci for coronary artery disease.

    Nat Genet 2013; 45:25-33.
  • ADIPOGen Consortium; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GEFOS Consortium; GENIE Consortium; GLGC; ICBP; International Endogene Consortium; LifeLines Cohort Study; MAGIC Investigators; MuTHER Consortium; PAGE Consortium; ReproGen Consortium,, et.al.


    New genetic loci link adipose and insulin biology to body fat distribution.adipose and insulin biology to body fat distribution.

    Nature 2015; 518(7538):187-96.
  • CARDIoGRAM+C4D Consortium et.al.


    Genetically determined height and coronary artery disease.

    N Engl J Med. 2015; 372(17):1608-18.